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Liraglutide in Type 1 Diabetes In a week trial, the GLP-1 agonist, liraglutide, was added on to insulin therapy in people with type 1 diabetes.
Patients were randomized to receive placebo or 1. Glucose was monitored with a continuous glucose monitor for four weeks before the trial and after the trial. At the end of treatment, HbA1c dropped from 7.
There was significant weight loss seen in the liraglutide group compared to the placebo group with a loss in weight of 2. With these results, GLP-1 agonists, such as liraglutide, show promising benefits in the treatment of type 1 diabetes.
Dandona, Paresh, et al. Supplement 1,doi: The First Oral GLP-1 Agonist GLP-1 agonists are used in the treatment of type 2 diabetes, to increase satiety, slow gastric emptying, help with weight loss, and of course improve glycemic control.
Semaglutide is in late stage development for the treatment of type 2 diabetes and will be known as the first oral GLP-1 receptor agonist. It is made in a tablet formulation and comes in 3, 7, or 14 mg. The tablet is taken once daily. The primary endpoint was to see a reduction in HbA1c after 26 weeks of treatment, and the secondary endpoint was to assess its efficacy without the need of rescue medication.
Semaglutide resulted in reductions in HbA1c and body weight. These results were seen at all doses. The most common adverse effect reported with Sema was mild to moderate nausea. This effect was transient.
Compared to placebo, semaglutide demonstrated better results in weight loss and reduction of HbA1c.
First, a single dose was given to people with type 2 diabetes in a cross-over study, where patients were given 2. Results showed that with 30 mg and mg, glucose was reduced and insulin secretions were reduced in 12 patients.
Patients given the mg dose experienced complete suppression of glucose and insulin excursions. In a separate phase of the study, 30 patients with type 2 were given 15 mg of LIK once daily for 14 days.
In a week randomized, double-blinded, placebo-controlled study, mg of LIK was administered to 88 patients who had type 2 and obesity.
Results of this test revealed weight loss of about 5. LIK was found to be safe and well-tolerated with the most common adverse effects reported to be headache, flatulence, and diarrhea.
Due to its effects on metabolic parameters and metabolic hormones, this dual inhibition from LIK appears to have great potential in the treatment of type 2 diabetes in patients with obesity. Nicotinimide N-methyltransferase Inhibitors Reduce Adipose Tissue, Hyperglycemia, and Insulin Resistance Because obesity is a leading cause of type 2 diabetes, drugs are in development to reduce adipose tissue.
A new drug class called nicotinamide N-methyltransferase NNMT inhibitors is being studied in diet-induced obese mice to assess its efficacy, oral bioavailability, and safety. The desired effects of this therapy is to regulate adipose tissue metabolism, and energy homeostasis.
Results showed a reduction in adipose cell size, weight reduction, reduced cholesterol levels, and overall reduction of white adipose tissue mass.
With these results, a drug class such as NNMT inhibitors may be used in the future to reduce the risk of type 2 diabetes caused by adiposity. Neelakantan, Harshini, and Stan Watowich.Key ADA poster summaries include liraglutide in type 1 diabetes, oral semaglutide, bottled water’s association with type 2 diabetes, & SGLT-2 combo LIK ADA: Liraglutide in Type 1 Diabetes In a week trial, the GLP-1 agonist, liraglutide, was added on to insulin therapy in people with type 1.
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Coronary Use. Safety Warning Caution: Temporary flushing, itching, or warming of the skin may occur. Do not use without the advice of your physician if you consume more than modest amounts of alcohol, have poorly controlled diabetes, liver disease, gout, active peptic ulcer disease, or unstable angina.
GLP-1 analogs and DPP-4 inhibitors Saturday 16 July, Keystone, Colorado Matthew C. Riddle Professor of Medicine Oregon Health & Science University Oregon.